人表皮生长因子受体2（HER2）生物标志物的免疫组织化学（IHC）染色在乳腺组织分析，临床前研究和诊断决策中广泛实践，指导癌症治疗和发病机制调查。 HER2染色需要由组织医学表演表演的艰苦组织处理和化学处理，这通常需要一天，以便在实验室中准备，增加分析时间和相关成本。在这里，我们描述了一种基于深度学习的虚拟HER2 IHC染色方法，其使用条件生成的对抗网络培训，训练以便将未标记/标记的乳房组织部分的自发荧光显微镜图像快速转化为明亮场当量的显微镜图像，匹配标准HER2 IHC染色在相同的组织部分上进行化学进行。通过定量分析证明了这一虚拟HER2染色框架的功效，其中三个董事会认证的乳房病理学家盲目地评级了HER2的几乎染色和免疫化化学染色的HER2整个幻灯片图像（WSIS），揭示了通过检查虚拟来确定的HER2分数IHC图像与其免疫组织化学染色的同类一样准确。通过相同的诊断师进行的第二种定量盲化研究进一步揭示了几乎染色的HER2图像在核细节，膜清晰度和染色伪像相对于其免疫组织化学染色的对应物的染色伪影等级具有相当的染色质量。这种虚拟HER2染色框架在实验室中绕过了昂贵，费力，耗时耗时的IHC染色程序，并且可以扩展到其他类型的生物标志物，以加速生命科学和生物医学工作流程的IHC组织染色。

Machine Reading Comprehension has become one of the most advanced and popular research topics in the fields of Natural Language Processing in recent years. The classification of answerability questions is a relatively significant sub-task in machine reading comprehension; however, there haven't been many studies. Retro-Reader is one of the studies that has solved this problem effectively. However, the encoders of most traditional machine reading comprehension models in general and Retro-Reader, in particular, have not been able to exploit the contextual semantic information of the context completely. Inspired by SemBERT, we use semantic role labels from the SRL task to add semantics to pre-trained language models such as mBERT, XLM-R, PhoBERT. This experiment was conducted to compare the influence of semantics on the classification of answerability for the Vietnamese machine reading comprehension. Additionally, we hope this experiment will enhance the encoder for the Retro-Reader model's Sketchy Reading Module. The improved Retro-Reader model's encoder with semantics was first applied to the Vietnamese Machine Reading Comprehension task and obtained positive results.

RTE is a significant problem and is a reasonably active research community. The proposed research works on the approach to this problem are pretty diverse with many different directions. For Vietnamese, the RTE problem is moderately new, but this problem plays a vital role in natural language understanding systems. Currently, methods to solve this problem based on contextual word representation learning models have given outstanding results. However, Vietnamese is a semantically rich language. Therefore, in this paper, we want to present an experiment combining semantic word representation through the SRL task with context representation of BERT relative models for the RTE problem. The experimental results give conclusions about the influence and role of semantic representation on Vietnamese in understanding natural language. The experimental results show that the semantic-aware contextual representation model has about 1% higher performance than the model that does not incorporate semantic representation. In addition, the effects on the data domain in Vietnamese are also higher than those in English. This result also shows the positive influence of SRL on RTE problem in Vietnamese.

To the best of our knowledge, this paper made the first attempt to answer whether word segmentation is necessary for Vietnamese sentiment classification. To do this, we presented five pre-trained monolingual S4- based language models for Vietnamese, including one model without word segmentation, and four models using RDRsegmenter, uitnlp, pyvi, or underthesea toolkits in the pre-processing data phase. According to comprehensive experimental results on two corpora, including the VLSP2016-SA corpus of technical article reviews from the news and social media and the UIT-VSFC corpus of the educational survey, we have two suggestions. Firstly, using traditional classifiers like Naive Bayes or Support Vector Machines, word segmentation maybe not be necessary for the Vietnamese sentiment classification corpus, which comes from the social domain. Secondly, word segmentation is necessary for Vietnamese sentiment classification when word segmentation is used before using the BPE method and feeding into the deep learning model. In this way, the RDRsegmenter is the stable toolkit for word segmentation among the uitnlp, pyvi, and underthesea toolkits.

Diabetic Retinopathy (DR) is a leading cause of vision loss in the world, and early DR detection is necessary to prevent vision loss and support an appropriate treatment. In this work, we leverage interactive machine learning and introduce a joint learning framework, termed DRG-Net, to effectively learn both disease grading and multi-lesion segmentation. Our DRG-Net consists of two modules: (i) DRG-AI-System to classify DR Grading, localize lesion areas, and provide visual explanations; (ii) DRG-Expert-Interaction to receive feedback from user-expert and improve the DRG-AI-System. To deal with sparse data, we utilize transfer learning mechanisms to extract invariant feature representations by using Wasserstein distance and adversarial learning-based entropy minimization. Besides, we propose a novel attention strategy at both low- and high-level features to automatically select the most significant lesion information and provide explainable properties. In terms of human interaction, we further develop DRG-Net as a tool that enables expert users to correct the system's predictions, which may then be used to update the system as a whole. Moreover, thanks to the attention mechanism and loss functions constraint between lesion features and classification features, our approach can be robust given a certain level of noise in the feedback of users. We have benchmarked DRG-Net on the two largest DR datasets, i.e., IDRID and FGADR, and compared it to various state-of-the-art deep learning networks. In addition to outperforming other SOTA approaches, DRG-Net is effectively updated using user feedback, even in a weakly-supervised manner.

Three main points: 1. Data Science (DS) will be increasingly important to heliophysics; 2. Methods of heliophysics science discovery will continually evolve, requiring the use of learning technologies [e.g., machine learning (ML)] that are applied rigorously and that are capable of supporting discovery; and 3. To grow with the pace of data, technology, and workforce changes, heliophysics requires a new approach to the representation of knowledge.

This study proposes an approach for establishing an optimal multihop ad-hoc network using multiple unmanned aerial vehicles (UAVs) to provide emergency communication in disaster areas. The approach includes two stages, one uses particle swarm optimization (PSO) to find optimal positions to deploy UAVs, and the other uses a behavior-based controller to navigate the UAVs to their assigned positions without colliding with obstacles in an unknown environment. Several constraints related to the UAVs' sensing and communication ranges have been imposed to ensure the applicability of the proposed approach in real-world scenarios. A number of simulation experiments with data loaded from real environments have been conducted. The results show that our proposed approach is not only successful in establishing multihop ad-hoc routes but also meets the requirements for real-time deployment of UAVs.

Image classification with small datasets has been an active research area in the recent past. However, as research in this scope is still in its infancy, two key ingredients are missing for ensuring reliable and truthful progress: a systematic and extensive overview of the state of the art, and a common benchmark to allow for objective comparisons between published methods. This article addresses both issues. First, we systematically organize and connect past studies to consolidate a community that is currently fragmented and scattered. Second, we propose a common benchmark that allows for an objective comparison of approaches. It consists of five datasets spanning various domains (e.g., natural images, medical imagery, satellite data) and data types (RGB, grayscale, multispectral). We use this benchmark to re-evaluate the standard cross-entropy baseline and ten existing methods published between 2017 and 2021 at renowned venues. Surprisingly, we find that thorough hyper-parameter tuning on held-out validation data results in a highly competitive baseline and highlights a stunted growth of performance over the years. Indeed, only a single specialized method dating back to 2019 clearly wins our benchmark and outperforms the baseline classifier.

Dataset scaling, also known as normalization, is an essential preprocessing step in a machine learning pipeline. It is aimed at adjusting attributes scales in a way that they all vary within the same range. This transformation is known to improve the performance of classification models, but there are several scaling techniques to choose from, and this choice is not generally done carefully. In this paper, we execute a broad experiment comparing the impact of 5 scaling techniques on the performances of 20 classification algorithms among monolithic and ensemble models, applying them to 82 publicly available datasets with varying imbalance ratios. Results show that the choice of scaling technique matters for classification performance, and the performance difference between the best and the worst scaling technique is relevant and statistically significant in most cases. They also indicate that choosing an inadequate technique can be more detrimental to classification performance than not scaling the data at all. We also show how the performance variation of an ensemble model, considering different scaling techniques, tends to be dictated by that of its base model. Finally, we discuss the relationship between a model's sensitivity to the choice of scaling technique and its performance and provide insights into its applicability on different model deployment scenarios. Full results and source code for the experiments in this paper are available in a GitHub repository.\footnote{https://github.com/amorimlb/scaling\_matters}

The devastation caused by the coronavirus pandemic makes it imperative to design automated techniques for a fast and accurate detection. We propose a novel non-invasive tool, using deep learning and imaging, for delineating COVID-19 infection in lungs. The Ensembling Attention-based Multi-scaled Convolution network (EAMC), employing Leave-One-Patient-Out (LOPO) training, exhibits high sensitivity and precision in outlining infected regions along with assessment of severity. The Attention module combines contextual with local information, at multiple scales, for accurate segmentation. Ensemble learning integrates heterogeneity of decision through different base classifiers. The superiority of EAMC, even with severe class imbalance, is established through comparison with existing state-of-the-art learning models over four publicly-available COVID-19 datasets. The results are suggestive of the relevance of deep learning in providing assistive intelligence to medical practitioners, when they are overburdened with patients as in pandemics. Its clinical significance lies in its unprecedented scope in providing low-cost decision-making for patients lacking specialized healthcare at remote locations.